|
KMID : 1177720210150010005
|
|
Journal of Alternatives to Animal Experiments
2021 Volume.15 No. 1 p.5 ~ p.14
|
|
|
Selection of Reference test Substances to Develop Alternative Test Methods for Immunotoxicity Evaluation
|
|
Kim Chang-Yul
Heo Yong
|
|
|
Abstract
|
|
|
|
Alternative test method for screening immunotoxic substances has not been actively challenged and no test guideline has been officialized internationally. Preparation of master list on reference chemicals is a critical process for decision on positive or negative immunotoxicity of test substances through alternative test method. The reference master list is recommended to include various scopes of immuntoxic xenobiotics including medicinal products, cosmetic ingredients, and industrial or environmental agents. Data bases or research results on human or animal immunotoxicity of chemicals were collected and analyzed for preparing the list of reference chemicals. Twenty eight chemicals were selected as non-immunotoxicants, which could be used as negative controls for immunotoxicity and 10 immunosuppressive drugs were chosen for classifying immunosuppressive toxicity of test substances. Considering chemicals used as positive controls for immunotoxicity, 38 substances with aberrant immune regulatory capacity were listed, which are categorized into 23 industrial or environmental agents, 12 medicinal products, and 3 agrochemicals. The list of reference test substances could contribute to development of in vitro alternative assay method for immunotoxicity evaluation.
|
|
|
KEYWORD
|
|
|
Immunotoxicity evaluation, Alternative assay method, In vivo immunotoxicity, Reference test substances
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|